The presidential firsts related to the family of the President of the United States.
| President | Note | |
|---|---|---|
| Children | ||
| First president with biological children | John Adams | |
| First president without biological children | George Washington | |
| First president with adopted children | George Washington | |
| First president to have 10 or more children | William Henry Harrison | |
| First president to have a child die while in office | John Adams | Charles Adams | 
| First president to have a child born in the White House | Grover Cleveland | |
| First president to have a child marry at the White House | James Monroe | |
| First president to have a son marry at the White House | John Quincy Adams | |
| Marriage | ||
| First president to have never wed | James Buchanan | |
| First president married in the White House | Grover Cleveland | |
| First president to be married at least 75 years | Jimmy Carter | |
| First president to be married to a member of Congress | Bill Clinton | Sen. Hillary Clinton, NY | 
| First president to be married to a Cabinet Member | Bill Clinton | Sec. State Hillary Clinton | 
| First president to be married to a presidential candidate | Bill Clinton | Hillary Clinton | 
| First president to marry a divorcee | Andrew Jackson | |
| First president to have been divorced | Ronald Reagan | Jane Wyman | 
| First president to have been widowed prior to inauguration | Thomas Jefferson | |
| First president widowed while in office | John Tyler | |
| First president to remarry while in office | John Tyler | |
| Parents | ||
| First president born to immigrant parents | Andrew Jackson | |
| First president born after the death of his father | Andrew Jackson | |
| First president whose father lived to see him become president | John Quincy Adams | Father, John Adams | 
| First president to have a parent live through his presidency | James Madison | Mother, Nelly | 
| First president to leave office while his father was still alive | Millard Fillmore | |
| First president to have both parents alive during his presidency | Ulysses S. Grant | |
| First president to leave office while both parents were still alive | George W. Bush | |
| First president to predecease a parent | James K. Polk | |
| First president to predecease his father | Warren G. Harding | |
| First president to predecease both parents | John F. Kennedy | |
| First president to be the son of another president | John Quincy Adams | Father, John Adams | 
| Second Generation | ||
| First president to be the grandson of another president | Benjamin Harrison | |
| First president to predecease a grandparent | John F. Kennedy | 
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